First report on laxative activity of Citrullus lanatus
نویسندگان
چکیده
This study was aimed to assess the possible laxative effect of aqueous fruit pulp extract of Citrullus lanatus in albino’s Wistar rats. Rats were divided in 5 groups of 6 animals each, first group as control, second group served as standard (sodium picosulfate) while group 3, 4 and 5 were treated with fruit pulp aqueous fruit pulp extract of Citrullus lanatus at doses of 250, 500 and 1000 mg/kg body weight (b.w.), per os respectively. The laxative activity was determined based on the weight of the faeces matter. The effects of the aqueous fruit pulp extract of Citrullus lanatus and reference standard on the gastro intestinal motility rate were also evaluated. Phytochemicals screening of the extract revealed the presence of flavonoids, tannins, polyphenols, sterols and polyterpenes. The aqueous fruit pulp extract of Citrullus lanatus administered orally at three different doses produced significant laxative activity and reduced loperamide induced constipation in dose dependant manner. The effect of the extract at 500 and 1000 mg/kg (p.o.) was similar to that of reference drug sodium picosulfate (5 mg/kg, p.o). The same doses of the extract (500 and 1000 mg/kg, p.o.) produced a significant increase (p < 0.01) of intestinal transit in comparison with castor oil (2 ml) (p < 0.01). The results showed that the aqueous fruit pulp extract of Citrullus lanatus has a significant laxative activity.
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